TABLE 7

OI values determined using the qualified OPA with human serum from a phase 1 study evaluating ExPEC4V

Subject no.VaccineOIa
Serotype O1ASerotype O2Serotype O6ASerotype O25B
Day 1Day 30Day 1Day 30Day 1Day 30Day 1Day 30
1ExPEC4V2491,45134012,9224917,62677226
2ExPEC4V1491,1512288,8974971,292338606
3ExPEC4V423,57816723,2104063,7842103,423
4ExPEC4V1229,6415609,8245414,55961,450
5ExPEC4V12615,20767426,2441,2923,3904761,265
6ExPEC4V1771,12148415,6098122,14086184
7ExPEC4V1475,88912810,3715092,4922387
8ExPEC4V3615105,38510,31850813,4072121,133
9ExPEC4V15477216,1352,0919,6554,6095,360
10ExPEC4V1733791877,2849992,759681
11Placebo229197374304353392265208
12Placebo197197230210404457320249
  • a OI, opsonization index. OI titers at or below the lower limit of quantification were replaced with the respective values of one-half the lower limit of quantification. Day 1 is prevaccination.