TABLE 1

Top seven candidates (together with known antigen Hcp1) identified via bioinformatics and immunoinformatics analyses

ProteinLocusPlacementSeroreactivityExpression
B. malleiB. pseudomalleiMHC-IMHC-II
HemagglutininBMAA1324BPSS0908120YesYes (22, 23)
FlgDBMA3327BPSL02724aUnknownUnknown
OmpWBMA2010BPSL270457UnknownIn vitrob (21)
FlgLBMA3336BPSL0281821UnknownUnknown
Porin OpcP1BMAA1122BPSS070893YesYes (22)
PorinBMAA0599BPSS0757124UnknownUnknown
Porin OpcPBMAA1353BPSS08791YesIn vitroc (21, 25)
Hcp1BMAA0742BPSS149813YesYes (14)
  • a —, not available.

  • b For 5.9% of B. pseudomallei OMPs.

  • c For 4.6% of B. pseudomallei OMPs and 2.5% of B. mallei OMPs.