TABLE 1

Response rates for IgG and IgA to Env and Gag measured 2 weeks post-DNA prime and 2 weeks post-VSV boost

Treatment groupResponse rate, % (no. positive/total)
6101 Env gp140Gag p24
PrimeBoostPrimeBoost
IgG
    Placebo0 (0/10)0 (0/9)0 (0/10)11.1 (1/9)
    Group 15 (1/20)5.3 (1/19)5 (1/20)15.8 (3/19)
    Group 20 (0/17)0 (0/17)5.9 (1/17)5.9 (1/17)
    Group 30 (0/20)0 (0/18)10.5 (2/19)15.8 (3/19)
    Group 45.6 (1/18)0 (0/15)0 (0/18)13.3 (2/15)
IgA
    Placebo0 (0/10)0 (0/9)0 (0/10)0 (0/9)
    Group 15 (1/20)0 (0/19)0 (0/20)0 (0/19)
    Group 20 (0/18)0 (0/18)5.6 (1/18)0 (0/18)
    Group 30 (0/21)0 (0/20)4.8 (1/21)5 (1/20)
    Group 45.3 (1/19)6.3 (1/16)0 (0/19)6.3 (1/16)