TABLE 4

IgG memory B-cell responses to GI.1 and GII.4 VLPs

Treatment groupDayGI.1GII.4
No. of participantsGeometric meana (95% CIb)No. of participantscGeometric mean fold rise (95% CI)% with 4-fold rise (95% CI)No. of participantsGeometric mean (95% CI)No. of participantsGeometric mean fold rise (95% CI)% with 4-fold rise (95% CI)
Placebo010.6 10.25
2810.2810.50.0 (0.0, 97.5)20.19 (0.00, 1,952.85)11.60.0 (0.0, 97.5)
5610.1510.30.0 (0.0, 97.5)20.34 (0.00, 211.37)10.80.0 (0.0, 97.5)
18010.09 20.42 (0.00, 101,101.8)10.60.0 (0.0, 97.5)
5/5 μg040.39 (0.08, 1.86) 70.21 (0.13, 0.35)
2895.11 (2.99, 8.73)47.9 (2.1, 29.2)75.0 (19.4, 99.4)91.58 (0.61, 4.07)67.8 (2.3, 26.3)83.3 (35.9, 99.6)
5686.80 (2.95, 15.68)37.9 (0.2, 310.3)66.7 (9.4, 99.2)81.46 (0.41, 5.23)58.3 (1.6, 41.4)80.0 (28.4, 99.5)
18084.59 (1.96, 10.74)45.8 (0.7, 46.6)75.0 (19.4, 99.4)91.07 (0.45, 2.56)74.6 (1.6, 13.4)57.1 (18.4, 90.1)
15/15 μg050.37 (0.17, 0.84) 60.43 (0.13, 1.38)
2874.63 (2.57, 8.34)49.8 (2.4, 40.3)100.0 (39.8, 100.0)82.11 (0.77, 5.77)54.3 (2.1, 8.7)40.0 (5.3, 85.3)
5655.95 (2.09, 16.98)312.7 (1.9, 86.3)100.0 (29.2, 100.0)62.19 (0.63, 7.54)54.5 (2.8, 7.4)80.0 (28.4, 99.5)
18075.81 (2.37, 14.20)48.0 (2.0, 31.2)75.0 (19.4, 99.4)81.33 (0.48, 3.72)62.4 (1.5, 3.7)16.7 (0.4, 64.1)
50/50 μg020.60 (0.00, 22,908.29) 10.14
2845.03 (0.77, 32.96)220.8 (0.1, 3,574.8)100.0 (15.8, 100.0)41.36 (0.09, 21.46)14.5100.0 (2.5, 100.0)
5646.99 (3.27, 14.93)214.9 (0.1, 3,481.6)100.0 (15.8, 100.0)42.84 (0.63, 12.89)17.1100.0 (2.5, 100.0)
18047.47 (3.23, 17.32)213.3 (0.0, 28768,477)100.0 (15.8, 100.0)41.63 (0.18, 14.64)11.60.0 (0.0, 97.5)
150/150 μg030.76 (0.04, 16.30) 50.51 (0.11, 2.43)
2876.66 (4.47, 9.93)219.1 (0.0, 20,444.4)100.0 (15.8, 100.0)74.04 (1.21, 13.52)55.9 (2.9, 11.9)80.0 (28.4, 99.5)
5677.07 (4.25, 11.77)39.5 (0.4, 215.4)100.0 (29.2, 100.0)72.94 (0.96, 8.97)54.0 (2.0, 7.9)60.0 (14.7, 94.7)
180715.63 (8.42, 29.00)326.1 (0.7, 1,026.9)100.0 (29.2, 100.0)71.54 (0.52, 4.58)52.3 (0.7, 8.3)40.0 (5.3, 85.3)
  • a The geometric mean percentage of VLP-specific memory B cells per 5 × 105 total memory B cells is given for each study group.

  • b CI, confidence interval.

  • c The second column headed “No. of participants” within each genogroup applies to fold change calculations. This number varied based on the number of participants for whom geometric mean numbers of memory B cells were available at baseline.