TABLE 1

Week 7 neutralization titers

Env group and animalID50 in TZM-bl cellsa
MN.3 virus, clade B, tier 1ABaL.26 virus, clade B, tier 1BBx08.16 virus, clade B, tier 1BTRO.11 virus, clade B, tier 2
Env-rFc
    811341<20<20<20
    81432<20<20<20
    81545<20<20<20
    819305<20<20<20
    821107<20<20<20
    82230<20<20<20
Env
    802<20<20<20<20
    809<20<20<20<20
    816<20<20<20<20
    817<20<20<20<20
    820<20<20<20<20
  • a Values are the serum dilutions at which relative luminescence units (RLU) were reduced 50% compared to the RLU of virus control wells (no test sample). The lower limit of detection is a neutralization titer of 20. All preimmunization titers were below 20 (data not shown).