TABLE 1

MHC class I and TRIM5α genotypes

Group and animal no.SexaMHC class I typebTRIM5α genotypecSusceptibilityscoredNo. of SIVmac251 exposuresAge (wk) at euthanasia
Group Ce
    44586FB*01, B*17Q/CypA−1416
    44618MB*01TFP/TFP0316
    44684FA*02, B*08TFP/TFP+2NPIf20
    44694FB*01TFP/TFP0115
    44696MB*17, B*29TFP/TFP+2115
    44698FB*01, B*08TFP/TFP+1114
    44718MA*01TFP/Q+1620
    44739MNegativegTFP/Q0520
    44746FA*01TFP/Q+1119
Group Dh
Group E
    42903FNegativeTFP/Q0121
    42918MA*01, B*01TFP/TFP+1NPI34
    42925FNegativeTFP/Q0121
    42943MA*01TFP/Q+1221
    42947FA*01TFP/CypA+2120
    42950MNegativeTFP/Q0120
Group F
    44146FB*17, B*29TFP/Q+1117
    44151FNegativeTFP/Q0217
    44155FB*01, B*17, B*29TFP/CypA+1117
    44159FA*11, B*17, B*29Q/Q0417
    44160FNegativeTFP/Q0NPI41
Group Gi
    44165MA*02, B*01TFP/TFP0NPI41
    44166MB*01TFP/TFP0116
    44169MB*01TFP/TFP0116
    44176MNegativeTFP/TFP+1218
    44180FA*08Q/Q−1118
    44186FA*02TFP/TFP+1117
    44195MA*08TFP/Q0117
  • a F, female; M, male.

  • b The Mamu A*01, B*08, and B*17 alleles have been associated with better disease outcome, whereas allele B*01 is associated with higher viremia.

  • c The TRIM5α genotypes TFP/TFP and TFP/CypA confer resistance to SIV, while the genotypes Q/Q and Q/CypA are associated with increased susceptibility to infection.

  • d Protective class I alleles and resistant TRIM5α alleles (A*01, B*08, TFP/TFP, and TFP/CypA) were assigned a value of 1. Genotypes associated with increased susceptibility or disease outcome received a score of −1. All other alleles were assigned a score of 0. The susceptibility score represents the sum of all scores for an individual animal (e.g., animal 42376 has MHC 1 + 0 + 1 + 0 and TRIM5α of 0 for a score of +2).

  • e In addition, group C includes the six naive control animals (group C1) described by Jensen et al. (9).

  • f NPI, not persistently infected.

  • g Negative, not positive for any of the Mamu class I alleles tested (A*01, A*02, A*08, A*11, B*01, B*03, B*04, B*08, B*17, and B*29).

  • h MHC class I and TRIM5α genotypes are published in the study by Jensen et al. (9).

  • i Note that group H is not included in this table, because animals received a high-dose SIV challenge and were used for week 9 immune activation measurements, but not for SIV risk calculations. Animals in groups A and B were not exposed to SIV.