MHC class I and TRIM5α genotypes

Group and animal no.SexaMHC class I typebTRIM5α genotypecSusceptibilityscoredNo. of SIVmac251 exposuresAge (wk) at euthanasia
Group Ce
    44586F B*01, B*17 Q/CypA−1416
    44618M B*01 TFP/TFP0316
    44684F A*02, B*08 TFP/TFP+2NPIf20
    44694F B*01 TFP/TFP0115
    44696M B*17, B*29 TFP/TFP+2115
    44698F B*01, B*08 TFP/TFP+1114
    44718M A*01 TFP/Q+1620
    44739MNegativeg TFP/Q0520
    44746F A*01 TFP/Q+1119
Group Dh
Group E
    42903FNegative TFP/Q0121
    42918M A*01, B*01 TFP/TFP+1NPI34
    42925FNegative TFP/Q0121
    42943M A*01 TFP/Q+1221
    42947F A*01 TFP/CypA+2120
    42950MNegative TFP/Q0120
Group F
    44146F B*17, B*29 TFP/Q+1117
    44151FNegative TFP/Q0217
    44155F B*01, B*17, B*29 TFP/CypA+1117
    44159F A*11, B*17, B*29 Q/Q0417
    44160FNegative TFP/Q0NPI41
Group Gi
    44165M A*02, B*01 TFP/TFP0NPI41
    44166M B*01 TFP/TFP0116
    44169M B*01 TFP/TFP0116
    44176MNegative TFP/TFP+1218
    44180F A*08 Q/Q−1118
    44186F A*02 TFP/TFP+1117
    44195M A*08 TFP/Q0117
  • a F, female; M, male.

  • b The Mamu A*01, B*08, and B*17 alleles have been associated with better disease outcome, whereas allele B*01 is associated with higher viremia.

  • c The TRIM5α genotypes TFP/TFP and TFP/CypA confer resistance to SIV, while the genotypes Q/Q and Q/CypA are associated with increased susceptibility to infection.

  • d Protective class I alleles and resistant TRIM5α alleles (A*01, B*08, TFP/TFP, and TFP/CypA) were assigned a value of 1. Genotypes associated with increased susceptibility or disease outcome received a score of −1. All other alleles were assigned a score of 0. The susceptibility score represents the sum of all scores for an individual animal (e.g., animal 42376 has MHC 1 + 0 + 1 + 0 and TRIM5α of 0 for a score of +2).

  • e In addition, group C includes the six naive control animals (group C1) described by Jensen et al. (9).

  • f NPI, not persistently infected.

  • g Negative, not positive for any of the Mamu class I alleles tested (A*01, A*02, A*08, A*11, B*01, B*03, B*04, B*08, B*17, and B*29).

  • h MHC class I and TRIM5α genotypes are published in the study by Jensen et al. (9).

  • i Note that group H is not included in this table, because animals received a high-dose SIV challenge and were used for week 9 immune activation measurements, but not for SIV risk calculations. Animals in groups A and B were not exposed to SIV.