TABLE 1

Parasitemia outcome in Aotus monkeys immunized with plasmid DNA/Ad5 encoding AMA1 and MSP142 in a prime/boost regimen against a Plasmodium vivax SAL-1 challengea

Group and monkey no.SexbWt (g)Mean (SD) prepatent period (days)ParasitemiaDay of MQ treatment and no. of monkeys treated/total no. of monkeys in groupc:Day of SC and no. of monkeys with SC/total no. of monkeys in groupDay of deathd
Day and mean (SD) day of peakPeak and mean (SD) peak no. of parasites (103)/μlGroup mean (SD) no. of parasites (103)/μlIndividual AUC and total group AUCBefore day 28Days 29–34Day 35
A
    13096176952150.4 273 35
    13107283061539.1 203 35
    12955196451695.0 825 35
    13165184082135.3 290 35
        Summary values 7 (2)18 (3)54.9 (27.4)13 (12)3980/40/44/40/4
B
    13144177461712.8 4721e
    13130191082634.5 216 35
    13131284571630.0 13221e
    13143180361775.8 34428e
    13141196781731.5 151 35
        Summary values 9 (3)19 (4)36.9 (23.3) 7.0 (7.4) f 2183/50/52/50/5
C
    13135287651559.2 272 35
    13168181951756.5 267 35
    13166192472045.6 217 23
    13145186661649.5 150 3534
    13146283061625 10821e
        Summary values 7 (1)17 (2)47.16 (13.5) 6.8 (10) f 2091/50/53/51/5
D
    13173186252339.5 199 34e 3235
    13156280561933.5 230 31 30
    13149184961636.8 226 35
    13157179652227.0 177 34 31
    13158276051710.7 67 31 27
        Summary values 6 (1)19 (3)29.4 (11.5) 5.8 (7.3) g 1800/54/51/5 4/5 f
E
    13090175881916.8 119 3534
    13091278152124.8 146 35
    13178289051672.4 297 35
    13179184851474.0 90 15
        Summary values 6 (1)17 (3)47.0 (30.4) 7.0 (10) h 2160/40/43/41/4
F
    13134169861648.3 315 35
    13076193661650.2 26728f
    13013291661622.5 94 31 28
    13177180061660.5 431 35
        Summary values 61645.38 (16.2)9.3 (12)i2871/41/42/41/4
G
    13190285541849.9 337 35
    131741764517111.0 612 35
        Summary values 4 (1)17 (1)80.5 (43.20)15 (22)i4740/20/22/20/2
  • a AUC, area under the parasitemia curve; MQ, mefloquine at 20 mg/kg orally once; SC, self-cured. Boldface indicates statistically significant different data.

  • b 1, male; 2, female.

  • c Rescue treated.

  • d The animals died of causes unrelated to malaria.

  • e The animal had anemia.

  • f P < 0.01.

  • g P < 0.0001.

  • h P < 0.001.

  • i ns, not significant.