TABLE 2

Comparison of nasal wash hemagglutinin-specific sIgA responses

ELISA target antigenVaccine groupMedian (range) NW anti-HA sIgA endpoint titerP valuea (pre- vs day 45 postvaccination)
PrevaccinationDay 45 postvaccination
Influenza A/H1N1 virus HAIIV18 (1.25–64)20.75 (1.25–2328)0.717
LAIV16.25 (3–41)28.5 (4–197)0.05
Influenza A/H3N2 virus HAIIV26.5 (5–69)31.5 (3–476)0.064
LAIV32.25 (1.25–88)57.25 (10–458)0.004
Influenza B virus HAIIV16 (3–50)16.5 (1.25–77)0.754
LAIV9.75 (3–47)16.75 (5–113)0.015
  • a Determined by the Wilcoxon matched-pair test. Day 0 (prevaccination) outliers (more than 1 standard error from the mean) were excluded.