TABLE 1

Affinity and germ line VR gene usage of MAbs 4C5 and 19A10

MAbKda (nM)VH gene and familyJH geneD geneVL familyVL geneJL gene
4C50.36 ± 0.072 X06868 , IGHV1S41*01IGHJ3*01bIGKV6-25*01 AJ235962 IGKJ2*01
19A100.24 ± 0.032 AJ851868 , IGHV2-9*02IGHJ3*01IGHD2-2*01IGKV1-117*01 D00081 IGKJ1*01
  • a Kd, dissociation constant.

  • b IMGT/junction analysis gives no results for this junction.