TABLE 1

Blood gases, plasma ions, and lactate at baseline and in sham-treated rats, saline controls, and ALM-treated rats over 6 daysa

Rat group (n)b and time pointpHpCO2 (mm Hg)pO2 (mm Hg)sO2 (%)K+ (mmol/liter)Na+ (mmol/liter)Ca2+ (mmol/liter)Cl (mmol/liter)Lactate (mmol/liter)
Baseline (8)7.43 ± 0.0138 ± 1109 ± 1100 ± 0.23.9 ± 0.2138 ± 2.41.28 ± 0.03102 ± 1.20.9 ± 0.1
2 h
    Sham (8)7.44 ± 0.0144 ± 1.5*86 ± 2*97 ± 0.5*4.3 ± 0.1141 ± 1.51.30 ± 0.04104 ± 0.60.9 ± 0.1
    Control (8)7.44 ± 0.0141 ± 0.686 ± 3*96 ± 1.2*4.7 ± 0.2*139 ± 1.51.27 ± 0.03104 ± 0.80.9 ± 0.1
    ALM (8)7.43 ± 0.0241 ± 391 ± 5*97 ± 1*4.7 ± 0.1*139 ± 0.91.22 ± 0.01105 ± 1.20.9 ± 0.1
Day 1
    Sham (8)7.42 ± 0.0148 ± 2*88 ± 3*96 ± 0.73.6 ± 0.0141 ± 1.81.33 ± 0.03100 ± 0.71.4 ± 0.1
    Control (8)7.42 ± 0.0350 ± 5*73 ± 10*82 ± 11*3.9 ± 0.2141 ± 1.01.31 ± 0.02101 ± 0.51.9 ± 0.5*
    ALM (8)7.41 ± 0.0147 ± 1.888 ± 3*95 ± 0.63.8 ± 0.2142 ± 1.51.34 ± 0.03101 ± 0.81.6 ± 0.2
Day 2
    Sham (8)7.49 ± 0.01*36 ± 1.492 ± 3*98 ± 0.8*4.5 ± 0*141 ± 0.51.33 ± 0.01103 ± 0.41.3 ± 0.1
    Control (2)7.53 ± 0.01*36 ± 0.8100 ± 0.1101 ± 0.54.4 ± 0141 ± 0.51.33 ± 0.05104 ± 1.50.7 ± 0.3
    ALM (7)7.52 ± 0.02*34 ± 1.6*101 ± 699 ± 0.74.6 ± 0.1*141 ± 0.91.34 ± 0.02*104 ± 0.71.2 ± 0.3
Day 4
    Sham (8)7.51 ± 0.01*35 ± 1.491 ± 2*98 ± 0.64.1 ± 0.0139 ± 1.41.32 ± 0.03103 ± 0.21.3 ± 0.2
    Control (2)7.53 ± 0.04*33 ± 4.0113 ± 9*100 ± 04.4 ± 0.1140 ± 0.51.34 ± 0.03104 ± 0.01.3 ± 0.4
    ALM (7)7.53 ± 0.01*33 ± 1.4*102 ± 798 ± 0.74.2 ± 0.1142 ± 0.71.36 ± 0.01*105 ± 1.11.1 ± 0.1
Day 6
    Sham (8)7.45 ± 0.0442 ± 5.784 ± 9*97 ± 1.63.9 ± 0.2140 ± 1.41.34 ± 0.02103 ± 0.61.1 ± 0.1
    Control (2)7.45 ± 0.0042 ± 2.385 ± 597 ± 2.83.0 ± 0.0142 ± 21.36 ± 0.02102 ± 0.01.5 ± 0.6
    ALM (7)7.47 ± 0.0239 ± 1.093 ± 397 ± 1.13.4 ± 0.1147 ± 3*1.40 ± 0.04*105 ± 1.71.2 ± 0.2
Death
    CED (4)7.31 ± 0.0859 ± 12*73 ± 3464 ± 22*5.7 ± 0.7*141 ± 1.31.37 ± 0.02103 ± 22.1 ± 0.7*
    CLD (2)7.45 ± 0.0239 ± 5.185 ± 2190 ± 93.6 ± 0.3145 ± 0.51.39 ± 0.01107 ± 12.0 ± 0.5*
    ALM LD (1)7.3059108972.91591.811071.20
  • a Values are for survivors through day 6, followed by animals with early and late death. *, P < 0.05, relative to baseline. CED, control early death; CLD, control late death; LD, late death.

  • b n = number of animals.