TABLE 2

Total WBC, neutrophil, lymphocyte, and monocyte counts and neutrophil/lymphocyte ratios at baseline and for sham-treated rats, controls, and ALM-treated rats over 6 daysa

Rat group (n) and time pointbTotal WBC count (109/liter)Neutrophil count (109/liter)Lymphocyte count (109/liter)Monocyte count (109/liter)Neutrophil/lymphocyte ratio
Baseline (8)9.07 ± 0.711.60 ± 0.197.21 ± 0.620.26 ± 0.050.2 ± 0.03
2 h
    Sham (8)7.41 ± 0.754.75 ± 0.51*2.2 ± 0.36*0.47 ± 0.092.4 ± 0.4*
    Control (8)8.56 ± 1.214.92 ± 1.09*3.05 ± 0.51*0.59 ± 0.14*1.8 ± 0.4*
    ALM (8)7.8 ± 0.834.79 ± 0.59*2.37 ± 0.25*0.64 ± 0.12*2.1 ± 0.2*
Day 1
    Sham (8)7.85 ± 0.54.82 ± 0.46*2.6 ± 0.13*0.43 ± 0.11.9 ± 0.2
    Control (8)4.82 ± 0.66^3.11 ± 0.49^1.5 ± 0.23+0.21 ± 0.032.1 ± 0.2*
    ALM (8)6.96 ± 0.59*4.8 ± 0.42*1.8 ± 0.2*0.37 ± 0.082.8 ± 0.3*
Day 2
    Sham (8)8.11 ± 0.924.41 ± 0.77*3.35 ± 0.38*0.35 ± 0.041.4 ± 0.4*
    Control (2)6.37 ± 0.043.40 ± 0.022.69 ± 0.07*0.29 ± 0.021.3 ± 0.04*
    ALM (7)7.74 ± 0.614.27 ± 0.34*3.13 ± 0.31*0.33 ± 0.031.4 ± 0.1*
Day 4
    Sham (8)11.68 ± 0.986.87 ± 0.93*4.24 ± 0.45*0.57 ± 0.111.7 ± 0.3
    Control (2)12.22 ± 6.338.95 ± 5.34*2.61 ± 0.72*0.67 ± 0.283.1 ± 1.2*
    ALM (7)13.43 ± 1.23*8.5 ± 1.12*3.93 ± 0.64*1.0 ± 0.16+3.0 ± 1.0*
Day 6
    Sham (8)9.9 ± 1.545.95 ± 0.95*3.23 ± 0.85*0.72 ± 0.19*2.8 ± 0.9*
    Control (2)9.88 ± 0.026.68 ± 0.12*2.54 ± 0.2*0.72 ± 0.022.7 ± 0.3
    ALM (7)9.14 ± 0.655.87 ± 0.5*2.6 ± 0.65*0.67 ± 0.13*3.0 ± 0.6*
Death
    CED (4)2.91 ± 1.02*1.69 ± 0.550.95 ± 0.41*0.26 ± 0.12.2 ± 0.3*
    CLD (2)12.79 ± 8.429.15 ± 5.94*2.92 ± 2.1*0.68 ± 0.34*3.5 ± 0.5*
    ALM LD (1)3.172.110.780.292.7
  • a Values are for survivors through day 6, followed by animals with early and late death. *, P < 0.05 versus value at baseline; ^, P < 0.05 versus values for all groups; ∼, P < 0.05 versus value for sham; +, P < 0.05 versus values for sham and baseline. CED, control early death; CLD, control late death; LD, late death.

  • b n = number of animals.