TABLE 6

Clearance of B. burgdorferi from infected ticks fed on immunized micea

ImmunogenChallenge strainNo. of ticks positive/total (%)
PBS-NMSB. burgdorferi B31-A36/9 (67)
Δp66 bacteriaB. burgdorferi B31-A31/8 (12.5)b
p66cp bacteriaB. burgdorferi B31-A30/8 (0)c
PBS-NMSB. burgdorferi N40 D10/E98/8 (100)
Δp66 bacteriaB. burgdorferi N40 D10/E912/13 (92)d
p66cp bacteriaB. burgdorferi N40 D10/E94/4 (100)d
  • a All mice were immunized four times and challenged with infected ticks 4 weeks after the last immunization. Five ticks were placed on each mouse for challenge. Replete ticks were collected and cultured to assess for the presence of Borrelia. In each group, Δp66- or p66cp-immunized mice were compared to the PBS-NMS-treated controls with Fisher's exact test in GraphPad Prism.

  • b P < 0.05.

  • c P < 0.01.

  • d No statistically significant difference.