MAb | k (1/Ms)_{a} | k (1/s)_{d} | K_{D} | χ^{2} |
---|---|---|---|---|

MAb502 IgG1 | 1.23 E+6 | 0.0063 | 5.12 E−9 | 1.97 |

MAb502 IgG3 | 1.46 E+6 | 0.0065 | 4.57 E−9 | 3.98 |

MAb502 IgGm15 | 1.05E+6 | 0.0061 | 5.75 E−9 | 3.06 |

MAb502 IgG1m17 | 1.06 E+6 | 0.0065 | 6.10 E−9 | 3.77 |

JAR3 IgG1 | 1.92 E+6 | 0.0007 | 0.36 E−9 | 5.60 |

JAR3 IgG3 | 1.94 E+6 | 0.0016 | 0.84 E−9 | 0.15 |

JAR3 IgG3m17 | 2.80 E+6 | 0.0021 | 0.76 E−9 | 2.56 |

↵a The data shown are the mean values for 2 replicates performed in two independent experiments.

*K*, equilibrium dissociation constant;_{D}*k*, association rate constant;_{a}*k*, dissociation rate constant; χ_{d}^{2}, quality of the fit of a 1:1 binding model to the data. The JAR3 IgG3m15 MAb construct was not expressed by the cell line, and the anti-PorA P1.16 MAbs were not tested because we lacked recombinant PorA that expressed the P1.16 epitope.