TABLE 2

Summary of clinical data from trial 1

VaccineCow no.Dose (Adt FFU/2 ml)Serum neutralization titer (log10 TCID50)No. of lesions at:Viral RNAaViremiabVirus sheddingc
0 dpc21 dpc2 dpc4 dpc8 dpcTime of viral RNA detection (dpc)RT-PCR resultDuration of detectable viral RNA (days)Time of viremia onset (dpc)Maximal viremia (TCID50/ml)Duration of viremia (days)Time of shed virus detection (dpc)Maximal virus shedding (TCID50/ml)Duration of shedding (days)
Adt.O1C.2B.RGD15 × 1091.53.30112SP100021 × 1032
22.12.4000NDNegNeg00023.2 × 1032
31.21.8000NDNegNeg00025.6 × 1031
41.22.40221SP400021 × 1052
Adt.O1C.2B55 × 1091.82.40113WP100025.6 × 1033
61.81.80003WP100021.8 × 1033
71.82.1000NDNegNeg00025.6 × 1022
81.83.60112WP100021.8 × 1063
Adt.Null135 × 109<0.33.34551SP515.6 × 102313.2 × 1064
14<0.31.54551SP411.8 × 103321.8 × 1053
15<0.31.23441SP415.6 × 103315.6 × 1045
16<0.31.21441SP511.8 × 103323.2 × 1043
  • a Detection of viral RNA in serum samples by RT-PCR. Results are expressed as follows: Neg, negative (CT of ≥40); WP, weak positive (CT of 35 to <40); SP, strong positive (CT of <35); ND, not detected.

  • b Detection of virus in serum samples. Virus titers are expressed as TCID50/ml.

  • c Detection of shed virus in nasal discharge fluid. Virus titers are expressed in TCID50/ml.