TABLE 3

Summary of clinical data from trial 2

VaccineCow no.Dose (Adt FFU/2ml)Serum neutralization titer (log10 TCID50)No. of lesions at:Viral RNAaViremiabVirus sheddingc
0 dpc21 dpc2 dpc4 dpc8 dpcTime of viral RNA detection (dpc)RT-PCR resultDuration of viral RNA detection (days)Time of viremia onset (dpc)Maximal viremia (TCID50/ml)Duration of viremia (days)Time of shed virus detection (dpc)Maximal virus shedding (TCID50/ml)Duration of shedding (days)
Adt.O1C.2B.RGD451 × 1091.52.70004WP200013.2 × 1033
461.52.7000NDNegNeg00011.8 × 1033
471.231442WP200013.2 × 1054
Adt.O1C.2B511 × 1091.22.7000NDNegNeg00025.6 × 1042
521.22.74451SP300025.6 × 1063
530.92.41112WP20000NoneNone
Adt.Null541 × 1090.92.72551SP615.6 × 103613.2 × 1055
55<0.33.63551SP425.6 × 103313.2 × 1064
56<0.33.35551SP415.6 × 104311.8 × 1065
  • a Detection of viral RNA in serum samples by RT-PCR. Results are expressed as follows: Neg, negative (CT of ≥40); WP, weak positive (CT of 35 to <40); SP, strong positive (CT of <35); ND, not detected.

  • b Detection of virus in serum samples. Virus titers are expressed in TCID50/ml.

  • c Detection of shed virus in nasal discharge fluid. Virus titers are expressed in TCID50/ml.