TABLE 1

Baseline titers and fold changes for IgA and IgG response to LPS, LTB, and CFA/I in serum ALS, fecal, and saliva samplesa

Antigen and antibodyBaseline titerFold increase of titer on day:
7102884
NRCRC/NNRCNRCNRCNRC
LPS
    Serum IgA13.7658.814.28**18.91**1.4059.63**1.6111.46**0.943.92*0.65
    Serum IgG146.7969.66.61**2.96**1.027.85**1.055.10**0.966.35**0.87
    ALS IgA0.370.260.701,093**18.2338.66**5.24**2.17*1.811.371.17
    Fecal IgA20.41425.920.9*NDND86.63*4.4221.34**3.596.111.53
    Parotid IgA697.6659.50.951.991.153.020.951.311.460.771.17
    Sublingual IgA794.5670.40.761.51.164.532.01.92.131.731.86
LTB
    Serum IgA237.3399.41.68*1.66*1.222.51**1.402.10**1.101.271.14
    Serum IgG632.5758.21.201.151.021.671.042.32**0.980.890.83
    ALS IgA0.410.190.4614.28**10.20**5.37**3.651.88**1.680.061.30
    Fecal IgA21.0373.973.52NDND2.372.953.632.433.741.12
    Parotid IgA4,4026,3321.440.960.321.621.060.691.240.490.25
    Sublingual IgA7,6285,2750.690.931.480.951.941.01.650.401.40
CFA/I
    Serum IgA168.4248.11.471.171.901.472.38*2.08**1.302.02*1.21
    Serum IgG366.5251.90.691.101.901.372.38*1.661.300.941.21
    ALS IgA0.360.782.174.14**4.93**1.812.112.17**1.270.820.29
    Fecal IgA12.439.300.75NDND0.421.610.550.661.940.94
  • a N, naive subjects; RC, rechallenged subjects; RC/N, fold increase of baseline titers in rechallenged compared to naive subjects; ND, not done. All the fold increases are compared to the baseline (the day before challenge in naive subjects and the day before rechallenge in rechallenged subjects). *, P < 0.05; **, P < 0.005.