TABLE 1

Antibody responses to VPR fusion protein before and following Norwalk virus challenge

SampleNo. of subjectsGMT (95% CI)aGMFRb (95% CI) from pre- to postchallengePostchallenge seroresponse frequency (% [95% CI])c
PrechallengePostchallenge (day 30)
Infected subjects5184 (65–110)449 (339–596)5.3 (4.1–7.0)74.5 (60.4–85.7)
    Gastroenteritis3879 (59–105)461 (337–630)5.9 (4.3–8.0)76.3 (59.8–88.6)
    No gastroenteritis13104 (53–205)418 (204–855)4.0 (2.2–7.2)69.2 (38.6–90.9)
Subjects not infected16135 (64–283)129 (63–262)1.0 (0.8–1.1)0 (0–20.6)
Infected vs. not infected P value0.134<0.001<0.001<0.001
  • a GMT, geometric mean titer; CI, confidence interval.

  • b GMFR, geometric mean fold rise.

  • c Four-fold or greater antibody titer rise to VPR protein from prechallenge.