TABLE 1

HAI and MN responses to homologous and heterologous H5N1 virus strains with AS03-adjuvanted or nonadjuvanted vaccine

H5 dose (μg) by virus strainAdjuvant usedAntibody response (95% CI) by assay ata:
6 mo postvaccination12 mo postvaccination
nHAIMNnHAIMN
GMT% HAI ≥40GMT% MN ≥40GMT% HAI ≥40GMT% MN ≥40
A/Indonesia/05/2005
    3.75AS034214.6 (10.8–19.7)24 (12–39)70.7 (57.1–87.5)93 (81–99)388.3 (6.6–10.6)8 (2–21)37.2 (28.6–48.4)58 (41–74)
    3.75None256.0 (5.1–7.0)0 (0–14)12.7 (9.4–17.1)16 (5–36)255.2 (5.0–5.5)0 (0–14)8.2 (6.7–10.1)0 (0–14)
    7.5AS034525.4 (18.9–34.1)44 (30–60)118.5 (96.0–146.2)100 (92–100)3910.1 (7.7–13.2)13 (4–27)57.6 (44.7–74.2)79 (64–91)
    7.5None265.0 (–)0 (0–13)9.2 (7.5–11.4)0 (0–13)245.0 (–)0 (0–14)7.4 (5.9–9.2)0 (0–14)
    15AS034325.5 (18.6–35.0)53 (38–69)157.4 (123.5–200.7)98 (99–100)4111.8 (8.9–15.7)17 (7–32)79.3 (61.4–102.5)88 (74–96)
    15None246.0 (4.9–7.5)4 (0–21)17.6 (11.6–26.6)21 (7–42)235.3 (4.7–6.0)0 (0–15)11.1 (7.8–15.9)9 (1–28)
A/Vietnam/1203/2004
    3.75AS03427.4 (5.8–9.4)7 (1–19)6.8 (6.1–7.5)0 (0–8)386.3 (5.1–7.9)3 (0–14)6.2 (5.6–6.8)0 (0–9)
    3.75None255.7 (4.8–6.6)0 (0–14)5.2 (5.0–5.5)0 (0–14)255.6 (4.8–6.5)0 (0–14)5.1 (4.9–5.2)0 (0–14)
    7.5AS034510.2 (7.8–13.3)11 (4–24)8.9 (7.6–10.4)4 (1–15)397.3 (5.8–9.2)3 (0–13)7.0 (5.9–8.3)3 (0–13)
    7.5None266.3 (5.1–7.7)0 (0–13)5.1 (4.9–5.2)0 (0–13)245.4 (4.8–6.1)0 (0–14)5.1 (4.9–5.2)0 (0–14)
    15AS034310.3 (7.7–13.9)9 (3–22)10.2 (8.5–12.1)2 (0–12)417.4 (5.7–9.7)7 (2–20)8.5 (7.2–10.1)0 (0–9)
    15None246.0 (5.0–7.3)0 (0–14)6.0 (5.0–7.2)0 (0–14)236.6 (5.0–8.7)4 (0–22)5.6 (4.8–6.6)0 (0–15)
A/Anhui/01/2005
    3.75AS03426.1 (5.3–7.1)0 (0–8)46.0 (39.6–53.5)76 (61–88)385.0 (5.0–5.1)0 (0–9)30.1 (24.3–37.4)50 (33–67)
    3.75None255.1 (4.9–5.2)0 (0–14)13.0 (10.2–16.6)4 (0–20)255.0 (–)0 (0–14)11.0 (9.1–13.3)0 (0–14)
    7.5AS03456.8 (5.7–8.1)2 (0–12)64.5 (53.8–77.3)96 (85–99)395.4 (4.9–5.9)0 (0–9)38.3 (31.1–47.1)59 (42–74)
    7.5None265.0 (–)0 (0–13)11.6 (9.1–14.7)8 (1–25)245.0 (–)0 (0–14)8.5 (6.8–10.7)0 (0–14)
    15AS03436.7 (5.6–8.0)2 (0–12)78.7 (64.6–95.9)95 (84–99)415.5 (4.9–6.2)0 (0–9)52.9 (42.5–65.7)73 (57–86)
    15None245.1 (4.8–5.5)0 (0–14)16.3 (11.6–23.0)17 (5–37)235.0 (–)0 (0–15)12.0 (8.9–16.2)9 (1–28)
A/turkey/Turkey/1/2005
    3.75AS03425.8 (4.9–7.0)5 (1–16)33.9 (28.8–40.0)50 (34–66)385.8 (4.7–7.1)5 (1–18)21.7 (17.2–27.3)34 (20–51)
    3.75None255.0 (–)0 (0–14)8.5 (6.7–10.7)0 (0–14)255.0 (–)0 (0–14)7.0 (5.9–8.2)0 (0–14)
    7.5AS034510.7 (7.5–15.2)24 (13–40)50.8 (41.6–62.0)73 (58–85)396.4 (5.1–7.9)5 (1–17)30.6 (24.2–38.8)33 (19–50)
    7.5None265.7 (4.3–7.5)4 (0–20)7.4 (6.2–8.7)0 (0–13)245.0 (–)0 (0–14)5.8 (5.2–6.4)0 (0–14)
    15AS03438.2 (6.3–10.8)9 (3–22)60.8 (49.6–74.6)84 (69–93)415.6 (4.8–6.5)5 (1–17)37.7 (29.8–47.7)59 (42–74)
    15None245.9 (4.2–8.1)4 (0–21)11.6 (8.2–16.2)13 (3–32)235.6 (4.5–6.9)4 (0–22)8.3 (6.4–10.9)4 (0–22)
A/Hubei/1/2010
    3.75AS03427.6 (5.8–10.6)14 (5–29)13.9 (11.5–16.8)7 (1–19)385.9 (4.6–7.5)5 (1–18)10.2 (8.4–12.4)5 (1–18)
    3.75None255.8 (4.4–7.8)4 (0–20)7.2 (5.9–8.8)0 (0–14)255.0 (–)0 (0–14)6.3 (5.5–7.3)0 (0–14)
    7.5AS03457.0 (5.4–9.1)9 (2–21)18.2 (15.1–22.1)18 (8–32)396.0 (4.8–7.4)5 (1–17)11.4 (9.2–14.1)8 (2–21)
    7.5None265.0 (–)0 (0–13)6.7 (5.5–8.2)0 (0–13)245.0 (–)0 (0–14)6.5 (5.5–7.6)0 (0–13)
    15AS03436.5 (5.1–8.4)7 (1–19)23.3 (18.4–29.5)21 (10–36)416.2 (4.8–8.1)5 (1–17)17.8 (13.3–23.8)20 (9–35)
    15None245.3 (4.7–6.0)0 (0–14)9.6 (6.7–13.6)8 (1–27)235.6 (4.8–6.5)0 (0–15)7.0 (5.2–9.3)4 (0–22)
  • a 95% CI, 95% confidence interval. The presence of a single dash in parentheses indicates that there is no range for the 95% CI.