TABLE 2

IgG antibody rates of change before and after 6 months of age

Assay/antigen tested (P. falciparum isolate)Time periodOdds ratio (95% CIa) per 1 mo age changePP difference between rates of changeb
Serology
    LSA1Before 6 moc0.72 (0.65–0.80)<0.001<0.001
After 6 mod1.04 (1.02–1.07)<0.001
    CSPBefore 6 mo0.64 (0.57–0.72)<0.001<0.001
After 6 mo1.04 (1.02–1.06)<0.001
    PfCelTOSBefore 6 mo1.16 (1.04–1.28)<0.0010.08
After 6 mo1.05 (1.03–1.07)<0.001
    SE50Before 6 mo1.20 (1.07–1.34)0.00250.03
After 6 mo1.04 (1.02–1.06)<0.001
    SE36Before 6 mo0.88 (0.80–0.98)0.010.003
After 6 mo1.04 (1.03–1.06)<0.001
    MSP142 (3D7)Before 6 mo0.75 (0.68–0.82)<0.001<0.001
After 6 mo1.04 (1.02–1.06)<0.001
    MSP142 (FVO)Before 6 mo0.79 (0.73–0.87)<0.001<0.001
After 6 mo1.05 (1.03–1.08)<0.001
    MSP142 (FUP)Before 6 mo0.66 (0.58–0.74)<0.001<0.001
After 6 mo1.05 (1.03–1.08)<0.001
    EBA140Before 6 mo0.85 (0.77–0.92)<0.001<0.001
After 6 mo1.06 (1.04–1.09)<0.001
    EBA175Before 6 mo0.76 (0.70–0.84)<0.001<0.001
After 6 mo1.05 (1.03–1.07)<0.001
    EBA181Before 6 mo0.75 (0.68–0.82)<0.001<0.001
After 6 mo1.06 (1.03–1.08)<0.001
    AMA1 (3D7)Before 12 mo0.76 (0.71–0.81)<0.001<0.001
After 12 mo1.03 (1.01–1.06)0.02
    AMA1 (FVO)Before 12 mo0.79 (0.75–0.83)<0.001<0.001
After 12 mo1.04 (1.01–1.07)0.003
Variant surface antigen assay
    BFD 2006Before 6 mo0.76 (0.69–0.84)<0.001<0.001
After 6 mo1.01 (0.99–1.03)0.33
    Msambweni 2006Before 6 mo0.60 (0.53–0.68)<0.001<0.001
After 6 mo1.02 (0.98–1.05)0.35
    3D7Before 6 mo0.63 (0.55–0.73)<0.001<0.001
After 6 mo1.01 (0.97–1.05)0.63
Growth and invasion inhibition assay
    Sial Dep IIABefore 6 mo1.18 (1.04–1.34)0.010.02
After 6 mo0.98 (0.93–1.04)0.56
    W2mef GIABefore 6 mo0.77 (0.68–0.89)<0.001<0.001
After 6 mo1.05 (1.00–1.10)0.07
    MSP1-19 IIABefore 12 mo1.03 (0.94–1.13)0.530.31
After 12 mo0.93 (0.81–1.08)0.35
    D10 GIABefore 12 mo0.86 (0.78–0.95)0.0040.07
After 12 mo1.05 (0.92–1.19)0.491
  • a CI, confidence interval.

  • b Difference between rates of change between birth to 6 (or 12) months of age and between 6 months of age and 36 months of age (Fisher's exact test).

  • c Compared to cord blood responses.

  • d Compared to 6-month responses.