TABLE 2

Serum marker analysis resultsb

MarkerGeometric avg/group:FDRaPost hoc testa
Past resolvedAcuteVascular chronic
Alpha-2-macroglobulin (mg/ml)1.171.991.330.158
Alpha-1-antitrypsin (mg/ml)2.253.723.550.037 ABC
Beta-2-microglobulin (μg/ml)2.032.132.700.337
Brain-derived neurotrophic factor (ng/ml)29.321.621.90.133
Complement C3 (mg/ml)1.442.451.670.002 ABD
C-reactive protein (μg/ml)3.2157.011.4<0.001 ABD
Eotaxin-1 (pg/ml)3691603340.002 ABD
Factor VII (ng/ml)6613734320.037 AB
Fibrinogen (μg/ml)13.925.614.50.067 A
Ferritin (ng/ml)161638990.001 ABD
Haptoglobin (mg/ml)1.874.172.430.163
Intercellular adhesion molecule 1 (ng/ml)1132011990.002 ABC
Gamma interferon (pg/ml)0.698.480.73<0.001 ABD
Interleukin-1 alpha (pg/ml)1.271.971.480.163
Interleukin-1 beta (pg/ml)1.692.161.560.343
Interleukin-1 receptor antagonist (pg/ml)112403133<0.001 ABD
Interleukin-6 (pg/ml)4.8735.267.690.004 ABD
Interleukin-8 (pg/ml)35.224.694.30.129
Interleukin-10 (pg/ml)2.926.393.480.159
Interleukin-12 subunit p70 (pg/ml)9.919.010.60.082 AB
Interleukin-15 (ng/ml)0.370.300.330.723
Interleukin-17 (pg/ml)2.422.311.670.413
Interleukin-18 (pg/ml)1772912900.082 AB
Interleukin-23 (ng/ml)1.841.851.790.989
Monocyte chemotactic protein 1 (pg/ml)2631742210.300
Macrophage inflammatory protein-1 alpha (pg/ml)56.224.9103.90.004 ABD
Macrophage inflammatory protein-1 beta (pg/ml)3184896760.103
Matrix metalloproteinase-2 (ng/ml)2.011.531.460.163
Matrix metalloproteinase-3 (ng/ml)8.166.058.820.447
Matrix metalloproteinase-9 (ng/ml)15.626.023.40.098 A
T-cell-specific protein RANTES (ng/ml)16.211.824.80.037 AD
Stem cell factor (pg/ml)2681992420.244
Tissue inhibitor of metalloproteinases 1 (ng/ml)1802101970.273
Tumor necrosis factor alpha (pg/ml)2.382.845.670.106
Tumor necrosis factor receptor 2 (ng/ml)9.513.614.10.129
Vascular cell adhesion molecule 1 (ng/ml)6988478050.413
Vitamin D-binding protein (μg/ml)2242393090.343
Vascular endothelial growth factor (pg/ml)8079129570.723
von Willebrand factor (μg/ml)44.852.354.90.337
  • a Significance is shown by uppercase letters as follows: A, significant in one-way ANOVA at an FDR of <10%; B, significant for post hoc comparison on past resolved versus acute Q fever group (FDR, <10%); C, significant for post hoc comparison on past resolved versus vascular chronic Q fever group (FDR, <10%); D, significant for post hoc comparison on acute versus vascular chronic Q fever group (FDR, <10%).

  • b A set of 39 serum markers were measured in three clinical groups (each for n = 10 samples): past resolved Q fever group, acute Q fever group, and vascular chronic Q fever group.