TABLE 1

Rationale for vaccine development for nontypeable Haemophilus influenzae

InfectionPopulation to vaccinateWhat vaccine will accomplish
Otitis mediaAll children beginning at 2 mo of agePrevention of:
    Acute otitis media
    Recurrent otitis media
    Chronic otitis media
    Otitis media with effusion related to bacterial biofilm formation
    Chronic suppurative otitis media
Reductions in:
    Excess antibiotic use
    Health care costs
Exacerbation of COPDAdults with COPDPrevention of:
    Acute exacerbations of COPD
    Chronic airway colonization
Reductions in:
    Excess antibiotic use
    Health care costs