TABLE 2

Haemophilus influenzae vaccine antigens under study

AntigenMolecular mass (kDa)FunctionReference(s)
Haemophilus adhesin protein (Hap)∼155Adhesin7173
HMW1, HMW2120–125Adhesins7476
H. influenzae adhesin (Hia)∼115Adhesin77, 78
D15 protein∼80Predicted nucleotidyltransferase79, 80
HtrA∼46Heat shock protein81
P2 porin36–42Porin protein65, 66, 82
Lipoprotein D∼42Glycerophosphodiester phosphodiesterase45, 56, 83
P5 fimbrin27–35Adhesin, OMP A-like protein51, 8486
P4 protein∼30Acid phosphatase8789
Protein F∼30Adhesin, ABC transporter9092
OMP 26∼26Skp family of translocation proteins85, 9395
P6 protein∼16Peptidoglycan-associated lipoprotein96102
Protein E∼16Adhesin, binds IgD103106
PilA (type IV pilus)∼14Adhesin, transformation51, 107109
Detoxified lipooligosaccharide3–5Endotoxin110113