TABLE 1

OMV immunization induces OMV-, LPS-, and CPS-specific serum IgG1, IgG2a, and IgG3

AntigenGroupGeometric mean titeraIgG1/IgG2a ratio
IgG1IgG2aIgG3
OMVNaive5050501
OMV31,037b17,269b12,679b1.8
LPSNaive115100501.2
OMV4,800c909b3,200c5.3
CPSNaive115100501.2
OMV3,482b1,056b348c3.3
• a The geometric mean of the reciprocal endpoint titer is indicated. Statistical significance was determined by comparing the OMV-immunized group with the naive group using the Mann-Whitney test. P < 0.05 was considered significant.

• b P = 0.01.

• c P = 0.009.