TABLE 1

GMTs of serum antibodies

GroupGMTa at:
Day 1 p.i.Day 2 p.i.Day 4 p.i.Day 6 p.i.
HAIMNIgMIgGHAIMNIgMIgGHAIMNIgMIgGHAIMNIgMIgG
VCI day −3<10<10151c (3/5)500c (4/5)<10<10348d (5/5)1516d (5/5)<1013d (1/8)951c (8/8)5657d (8/8)269 (8/8)494c (8/8)4526d (8/8)20749d (8/8)
VCI day −2NDbND<200<500<10<10152 (3/5)<500 (0/5)<10<10696c (5/5)1,149 (5/5)226 (6/6)202 (6/6)2,851 (6/6)8,000 (6/6)
VCI day −1NDND<200<500<10<10174 (4/5)<500 (0/5)<10<10303 (5/5)758 (5/5)211 (5/5)160 (5/5)1,393 (6/6)4,000 (5/5)
Vaccine day −3NDND<200<500<10<10174 (4/5)435 (3/5)<10<10336 (8/8)1,682 (8/8)119 (6/7)54 (5/7)1,600 (7/7)4,876 (6/7)
Imiquimod day −3NDND<200<500<10<10<200<500<10<10<200500 (3/8)10 (2/8)11 (2/8)200 (5/8)1,834 (7/8)
PBS<10<10<200<500<10<10<200<500<10<10<200<500<10<10119 (3/9)354 (3/9)
  • a An HAI assay titer of ≥1:40 was considered positive. Vaccine day −3, vaccine alone given 3 days prior to virus infection. An MN assay titer of ≥1:40 was considered positive. The values in parentheses are the number positive/number tested.

  • b ND, not done.

  • c P < 0.01 compared with the vaccine-alone group (Mann-Whitney U test).

  • d P < 0.05 compared with the vaccine-alone group (Mann-Whitney U test).