TABLE 2

Flagellin as an adjuvant in chicken: applications in vitro

Cell categoryResponse(s)Reference
Chicken PBMCsUpregulation of both IL-12 and IL-4 as well as IL-679
Chicken splenocytesInduction of a mixed Th1- and Th2-like response80
Chicken heterophilsUpregulation of IL-6 and CXCLi2100
HeLa cells with chicken TLR5Upregulation of TLR5-flagellin-mediated NF-κB expression72
Chicken monocytesInduction of nitric oxide production78
Chicken heterophilsIncreased oxidative burst; significant production of proinflammatory cytokines and chemokines77
CEF, CKC HD11 cellsSignificant upregulation of IL-1β23
Chicken heterophilsSignificant upregulation of IL-1β, IL-6, and IL-8 and increased oxidative burst76