TABLE 2

Protection of mice from Helicobacter pylori SS1 infection following immunization with live recombinant L. acidophilus

VaccineNo. of mice colonized by H. pylori (of 10 mice immunized)Hp0410 in mouse gastric mucosa (mean ± SD) (log CFU/g)Chronic gastric inflammation scorea (mean ± SD)
Urease testCatalase test
Noneb10106.02 ± 0.012.22 ± 0.21
pMG36ec10106.28 ± 0.601.49 ± 0.64
pMG36e-hp0410d004.55 ± 0.17e,f1.21 ± 0.17e
  • a Histopathological findings for infected mice were assessed in H&E-stained gastric mucosal sections. Gastric inflammation was graded on a scale of 0 to 3 for each group.

  • b Orally immunized with PBS.

  • c Orally immunized with recombinant L. acidophilus containing pMG36e.

  • d Orally immunized with recombinant L. acidophilus containing pMG36e-hp0410.

  • e P < 0.05 versus control group.

  • f P < 0.05 versus pMG36e group.