Table 1

Significant effects of sleep deprivation on cytokine levels measured by three different assays

Assay type and cytokine testedData for each groupa
ControlCFS
NormalSleep deprivationNormalSleep deprivation
ELISPOT assay (n)1213
    IL-1βb94.2 ± 70.0140.1 ± 94.125.7 ± 13.140.7 ± 13.2e
    IL-8b37.2 ± 11.556.1 ± 16.3e60.1 ± 12.269.8 ± 11.7
Luminex assay (n)910
    IL-1βc0.03 ± 0.020.08 ± 0.04e0.18 ± 0.070.14 ± 0.05
qRT-PCR assay (n)1315
    IL-4d0.76 ± 0.330.29 ± 0.11e0.42 ± 0.131.34 ± 0.92
    IL-10d0.55 ± 0.150.50 ± 0.180.36 ± 0.060.25 ± 0.03e
  • a The statistical tests were conducted with log-transformed data. Values in bold type indicate significant cases.

  • b No. of cytokine-producing cells (mean ± SE) (raw data).

  • c Cytokine level (mean ± SE) (pg/ml) (raw data).

  • d Cytokine level (relative quantity) (mean ± SE) (raw data).

  • e Significant within-group difference from normal night.