Table 3

Invasive potential of S. pneumoniae isolates

PCV group and serotypeaNo. of strainsNo. of isolates by typeOR (95% CI)b
IPDNoninvasive
PCV7
    1453210.3 (1.7–62.1)
    43123.4 (0.3–37.6)
    18C3123.4 (0.3–37.6)
    9V5141.7 (0.2–15.2)
    23F142121.1 (0.2–5.1)
    6B152131.0 (0.2–4.6)
    19F859760.8 (0.4–1.6)
PCV13
    532113.7 (1.2–151.5)
    7F2213910.5 (4.4–25.1)
    3356291.4 (0.6–3.5)
    19A389513381.0 (0.7–1.5)
    6A271260.3 (0.03–1.9)
    1330
Non-PCV
    12F/B86221.0 (4.2–105.0)
    11E2116.8 (0.4–109.0)
    10A/395234.5 (0.8–27.4)
    17F/A11473.9 (1.1–13.6)
    23A13493.0 (0.9–10.0)
    23B164122.3 (0.7–7.2)
    22F/A336271.5 (0.6–3.7)
    15B/C678590.9 (0.4–1.9)
    9N9180.8 (0.1–6.8)
    35F/47F9180.8 (0.1–6.8)
    6C757680.7 (0.3–1.5)
    15A/F252230.6 (0.1–2.5)
    16F242220.6 (0.1–2.6)
    33F/A312290.5 (0.1–1.9)
    35B1036970.4 (0.2–0.9)
    11A/D/F391380.2 (0.02–1.3)
    NT11541110.2 (0.1–0.6)
    7B/C/40707
    31606
    34404
    21303
    13110
Total1,2151571,058
  • a NT, nontypeable. Each serotype group is ordered by invasive potential.

  • b OR, odds ratio; CI, confidence interval. An OR of >1 indicates increased invasive potential, whereas an OR of <1 indicates decreased invasive potential. ORs (95% CI) are considered statistically significant at a P value of <0.05 (shown in bold type).