Table 2

Immune sera generated from different species and anthrax vaccinesa

SpeciesTotal no. of samplesVaccine used (no. of samples)No. of immunizationsInjection route
rPA + AlhydrogelAVAAVA + CPG 7909
NHP1501502bi.m.
Rabbit4508371 or 2ci.m.
Human1200122i.m.
Mouse32111291i.p.
  • a Serum samples were obtained from nonhuman primates (NHP), rabbits, humans, and mice that were immunized with one or two injections of vaccine via intraperitoneal (i.p.) or intramuscular (i.m.) injections.

  • b NHP subjects were exposed to a lethal aerosolized dose of Bacillus anthracis spores after the second injection.

  • c Fifteen samples were derived from one immunization and 30 from two immunizations (7 AVA and 23 AVA/CPG 7909 sera were derived from animals that received two immunizations).