Table 1

Comparison of BioPlex 2200 Syphilis IgG, ARCHITECT Syphilis TP, and TPHA to IgG WB assay

Assay and resultIgG WB result (no. of samples)% sensitivity (95% CI)% specificity (95% CI)% agreement (95% CI)κ value
PositiveNegative
BioPlex 2200 Syphilis IgG
    Positive35248100 (99–100)89.7 (86.6–92.3)94.2 (92.5–95.8)0.88
    Negative0420
ARCHITECT Syphilis TP
    Positive352101100 (99–100)78.4 (74.4–82.1)87.7 (85.4–89.9)0.76
    Negative0367
TPHA
    Positive351199.7 (98.5–99.9)99.8 (98.8–100)99.8 (99.4–99.9)0.98
    Negative1467