Table 2

Diagnostic accuracy of CD-specific serologic testsa

TestbSensitivity (%) (range)Specificity (%) (range)PPVc (%)NPVc (%)No. of studies
AGA IgA85 (57–100)90 (47–94)18995
AGA IgG85 (42–100)80 (50–94)31995
EMA IgA95 (86–100)99 (97–100)83996
tTG IgA98 (78–100)98 (90–100)72997
tTG IgG70 (45–95)95 (94–100)42997
DGP IgA88 (74–100)95 (90–99)44997
DGP IgG80 (63–95)98 (90–99)68997
  • a Adapted from the review by Leffler and Schuppan (41) with permission from Macmillan Publishers Ltd., based on the studies conducted from 1999 to 2010.

  • b Abbreviations: AGA, antigliadin antibodies; DGP, deamidated gliadin peptide; EMA, endomysial antibodies; IgA, immunoglobulin A; IgG, immunoglobulin G; tTG, tissue transglutaminase.

  • c The positive predictive value (PPV) and negative predictive value (NPV) both had a pretest probability of 5%.