Table 1

Diagnostic performance of CD serologic testsa

Test and groupbSensitivity (%) (range)Specificity (%) (range)No. of studies
AGA IgA
    Adults66.5 (31–100)94 (87–92)6
    Children95.8 (90–100)94.5 (86–100)4
AGA IgG
    Adults69 (46–95)92 (87–98)6
    Children95 (91–100)88.7 (67–100)3
ARA IgA
    Adults71.2 (41–92)98.8 (95–100)5
    Children72.6 (29–100)99.6 (98–100)5
EMA IgA
    Adults93 (89–100)98.8 (95–100)5
    Children100 (100)100 (100)3
  • a Adapted and modified from Tables 1 and 3 in the review by Maki (25) with permission from Elsevier. AGA test results are based on studies conducted from 1983 to 1994, ARA test results are based on studies conducted from 1971 to 1994, and EMA test results are based on studies conducted from 1974 to 1994.

  • b Abbreviations: AGA, antigliadin antibodies; EMA, endomysial antibodies; IgA, immunoglobulin A; IgG, immunoglobulin G.