Table 3

Diagnostic performance of CD-specific serologic assays in adult patientsa

TestbSensitivity (%) (range)Specificity (%) (range)Positive LHRc (range)Negative LHR (range)No. of studies
AGA IgA0.65 (0.46–0.87)0.91 (0.70–0.98)17.9 (2.59–41.9)0.38 (0.14–0.55)6
AGA IgG0.62 (0.25–0.93)0.90 (0.80–0.97)10.1 (4.67–17.8)0.41 (0.08–0.76)5
me-EMA IgA0.91 (0.74–1.0)0.99 (0.97–1.00)149 (26.3–495)0.12 (0.05–0.28)8
hr-tTG IgA0.90 (0.80–1.00)0.96 (0.91–0.99)48 (9.99–109.9)0.108 (0.02–0.21)7
tTG IgG0.72 (0.27–1.00)0.88 (0.77–0.95)8.48 (8.8–12.7)0.31 (0.06–0.74)3
  • a Adapted and modified from Table 4 in the review by van der Windt et al. (32) with permission of the publisher (Copyright © 2010, American Medical Association. All rights reserved). Results are based on the search conducted in MEDLINE (beginning in January 1966) and EMBASE (beginning in January 1947) through December 2009.

  • b Abbreviations: AGA, antigliadin antibodies; me-EMA, monkey esophagus endomysial antibodies; hr-tTG, human recombinant tissue transglutaminase; IgA, immunoglobulin A; IgG, immunoglobulin G.

  • c LHR, likelihood ratio.