Table 3

Amino acid sequence similarity of selected M. leprae-specific proteinsa

Protein subclassORFMolecular mass (kDa)Sequence similarity (E value)Mycobacterial protein(s) with amino acid sequence similarityb
VI.aML00709.1NoneNA
ML01419.3NoneNA
ML044810NoneNA
ML05278.7NoneNA
ML057411.4NoneNA
ML095913.6NoneNA
ML10108.4NoneNA
ML138412.2NoneNA
ML157511.1NoneNA
ML20447.9NoneNA
ML265111.6NoneNA
ML26668.8NoneNA
VI.bML01219.63e−08Hypothetical proteins of M. paratuberculosis
ML002311.73e−06
ML01889.23e−08Conserved hypothetical unknown of M. paratuberculosis
ML02178.41e−06
ML05739.51e−05Hypothetical protein of M. kansasii
ML05888.53e−04PPE protein of M. tuberculosis
ML09538.61e−06Putative nucleic acid binding protein of M. kansasii
VI.cML061410.23e−17Hypothetical proteins of M. tuberculosis T46
ML2630137e−10Conserved membrane protein of M. tuberculosis T92
ML194912.55e−17Hypothetical proteins of M. kansasii
VI.dML07559.61e−22Hydrolase of M. kansasii
ML09206.31e−102Hypothetical protein of M. tuberculosis T17
ML23079.34e−52Transcription factor WhiB4 of M. paratuberculosis
ML231321.83e−71Transcriptional regulator (PadR) of M. avium 104
  • a All ORFs in subclass VI.a appear to have no homology. M. leprae proteins with BLASTP values between 1 × 10−4 and 1 × 10−8 are considered to have low homology (subclass VI.b). Proteins with E values between 1 × 10−8 and 1 × 10−20 have moderate homology (subclass VI.c), and those with E values of <1 × 10−20 have high homology (subclass VI.c).

  • b Most similar one among several proteins found in BLASTP. NA, not applicable.