Table 1

Comparison of three cryptococcal antigen assays to the latex agglutination test using serum specimens (n = 634)a

Assay and resultNo. of samples with the following Meridian LA test result:Sensitivity (%) (95% CI)Specificity (%) (95% CI)Agreement (%) (95% CI)Kappa
PositiveNegative
Premier EIA
    Positive5055.6 (26.6, 81.2)100 (99.3, 100)99.4 (98.3, 99.8)0.71
    Negative4625
Alpha CrAg EIA
    Positive92b100 (65.5, 100)99.7 (98.8, 99.9)99.7 (98.8, 99.9)0.90
    Negative0623
CrAg LFA
    Positive91c100 (65.5, 100)99.8 (99.0, 100)99.8 (99.0, 99.9)0.95
    Negative0624
  • a LA, latex agglutination; EIA, enzyme immunoassay; LFA, lateral flow assay; 95% CI, 95% confidence interval.

  • b One of these two samples showed 1+ reactivity by the Meridian latex agglutination assay upon screening but was interpreted as negative according to the package insert's requirement for 2+ reactivity.

  • c This sample showed 1+ reactivity by the Meridian latex agglutination assay upon screening but was interpreted as negative according the package insert's requirement for 2+ reactivity.