Table 2

Comparison of four cryptococcal antigen assays to a consensus of the test panel using serum specimens (n = 633)a

Assay and resultNo. of samples with consensus of test panel resultsbSensitivity (%) (95% CI)Specificity (%) (95% CI)Agreement (%) (95% CI)Kappa
PositiveNegative
Meridian LA
    Positive90100 (65.5, 100)100 (99.3, 100)100 (99.3, 100)1.0
    Negative0624
Premier EIA
    Positive5055.6 (26.6, 81.2)100 (99.3, 100)99.4 (98.3, 99.8)0.71
    Negative4624
Alpha CrAg EIA
    Positive91100 (65.5, 100)99.8 (99.0, 99.9)99.8 (99.0, 99.9)0.95
    Negative0623
CrAg LFA
    Positive90100 (65.5, 100)100 (99.3, 100)100 (99.3, 100)1.0
    Negative0624
  • a LA, latex agglutination; EIA, enzyme immunoassay; LFA, lateral flow assay; 95% CI, 95% confidence interval.

  • b A consensus of the test panel results was defined as at least 3 of 4 cryptococcal antigen results being in agreement. There was one sample that did not yield a consensus result; therefore, only 633 sera were included in this analysis.