Table 1

Sequence identity mapping of proteins that were upregulated in response to stress conditions

ProteinMass (kDa)M. avium subsp. paratuberculosis strain(s)aRegulation in response to in vitro stress conditionsbSequence identity (%)c
THSROIRNIM. avium subsp. paratuberculosis K-10M. avium subsp. hominissuis 104M. avium subsp. avium ATCC 25291
MAP0187c23.0S1009999
MAP054017.6C100100100
MAP1017c27.8C1009999
MAP1168c31.9C1009999
MAP129725.3S1009999
MAP156015.2C10010099
MAP1588c18.8C10099100
MAP1589c21.6C, S1009999
MAP165316.4C1009999
MAP1698c16.3C1009999
MAP1834c27.9S100100100
MAP2058c25.4C10099100
MAP2312c41.4C, S1009999
MAP2487c17.8C1009999
MAP2698c31.4C1009999
MAP2872c26.7C1009999
MAP326816.4C1009999
MAP3393c17.5C1009999
MAP3523c62.3S100NA99
MAP353815.9C10010096
MAP356730.1C1009999
MAP3651c43.9C1009999
MAP3974c18.6S10039*
MAP409818.7C100100100
MAP434012.4C10099NA
  • a C, cattle strain; S, sheep strain.

  • b T, temperature flux (18); H, hypoxia; S, nutrient starvation (16); ROI, oxidative stress; RNI, nitrosative stress (22); ↑, upregulated.

  • c Values in bold indicate 100% sequence identity only to M. avium subsp. paratuberculosis K-10, and the corresponding proteins were selected for epitope prediction. NA, sequence identity data not available at NCBI; *, the MAP3974c protein revealed 39% and 99% sequence identities to the hypothetical proteins MaviaA2_17319 and MaviaA2_20904, respectively, both from Mycobacterium avium subsp. avium ATCC 25291.