Table 2

Numbers of conformational B cell and T cell (MHC class I and II) epitopes

ProteinaPDB IDbNo. of B cell epitopes at prediction cutoff scoreNo. of T cell epitopesc
MHC class I T cell epitopesMHC class II T cell epitopes
0.50.60.70.80.9LIHLIH
MAP12972VEP5793023412254
MAP16531Y2544222155113812
MAP3393c1O4V544321586114910
MAP2872cc2ZAT495542417321313
MAP1589c2BMX8763318331181
MAP43401NW2872211063103
MAP2698ca1ZA077743249992565
MAP1168cb1EZW9764228872267204
MAP3567ac1ZBQ1012952268742685
MAP1017c3H817764324942249
MAP2487c1YLK5642214861409
MAP32681SHS4454213811133
MAP1698c1SHS88642133411311
MAP3651cac2PGO10101010638110638110
MAP3523cabc2Q279799557013353941
MAP0187cb1GN3674211888317518
MAP2312cac1JQI687853641153731
MAP3974c16321160
  • a Proteins are marked as follows. a, proteins with the largest numbers of MHC class I T cell epitopes; b, proteins with the largest numbers of MHC class II T cell epitopes; c, proteins with the largest numbers of conformational B cell epitopes.

  • b PDB ID of the 3D structural template for each M. avium subsp. paratuberculosis protein. A detailed description of the source of each template is presented in Table S4 in the supplemental material.

  • c L, low-affinity binding; I, intermediate-affinity binding; H, high-affinity binding.