Table 1

Association and dissociation rate constants and apparent binding constants for MAbs in this studya

IgGkon (1/M-s) (105)koff (1/s) (10−4)KD (nM)χ2
2A3.113.78.210.6010.433
10A7.56.923.490.5040.345
12B8.195.752.780.4850.288
28F6.10.678.8113.10.906
  • a Association (kon) and dissociation (koff) rate constants were measured using a BIAcore instrument, and the apparent binding constants (KD) were calculated as koff/kon.