Table 2

SNPs examined in the TLR3 and CD44 genes in the initial and replication studies

Gene and SNPP valuea
Initial genetic studyReplication study
School-aged childrenInfants
IgGbSBAcIgGbSBAcSBAd
12221222122212221222
TLR3
    rs76571860.520.070.540.080.002***0.200.760.290.93
    rs57433120.070.050.670.041.00*1.000.88*1.00*0.910.46
    rs37752920.680.030.930.480.14*1.00*0.820.641.000.80
    rs37752910.030.560.370.880.14*1.00*0.310.940.990.77
CD44
    rs3536440.160.880.020.501.001.000.570.070.360.28
    rs110330130.030.030.651.00
    rs47561960.560.640.050.35
    rs124190620.380.490.360.500.01***0.760.190.190.21
  • a Adjusted logistic regression models were used. The P values shown are for genotype 12 (heterozygous variant) or 22 (homozygous variant) compared to the homozygous wild-type genotype (11 = baseline) for IgG or SBA (with significant values shown in bold). Subjects were separated into responders (IgG level of ≥2 μg/ml or SBA level of ≥1:8) and nonresponders (IgG level of <2 μg/ml or SBA level of <1:8) for analysis. The initial genetic study contained 905 individuals, and the replication cohort comprised school-aged children (n = 155) and infants (n = 196). Gray shading denotes SNPs that were not examined in the replication cohort. *, Fisher's exact P value is reported because no responders were observed; **, no wild-type or variant homozygous nonresponders were observed.

  • b With adjustment for age at measurement.

  • c With adjustment for age at measurement and vaccine type.

  • d With adjustment for vaccine type.