Table 2

Comparison of mean differences between HBsAg quantification methods by various clinical parametersa

Clinical parameterNo. of sampleseMean differencebLimit of agreement (±2 SD)
HBeAg status
    HBeAg positive690.182−0.560, 0.923
    HBeAg negative570.143−0.500, 0.786
HBV DNA viral load
    >2,000 IU/ml750.180−0.655, 1.014
    ≤2,000 IU/ml510.141−0.284, 0.566
HBV genotypec
    A590.196−0.564, 0.956
    D70.036−0.165, 0.237
    E70.030−0.251, 0.311
    G+A/G150.201−0.275, 0.676
Precore (W28) mutation
    Yes230.111−0.279, 0.500
    No630.195−0.543, 0.933
YMDD mutation
    Yes600.156−0.543, 0.855
    No200.234−0.403, 0.871
s120/s145 mutationsd
    Yes6−0.078−0.403, 0.247
    No810.186−0.487, 0.859
HCV-positive serology
    Yes150.160−0.924, 1.243
    No1100.164−0.473, 0.802
HDV-positive serology
    Yes90.251−0.485, 0.988
    No1160.157−0.541, 0.856
CD4+ T cell count
    >500 cells/mm3420.195−0.341, 0.732
    350–500 cells/mm3360.155−0.791, 1.102
    <350 cells/mm3480.143−0.464, 0.751
  • a Bland-Altman analysis stratified on various HBV and HIV cofactors.

  • b Difference of Elecsys to Architect.

  • c P values of <0.1 when mean between-assay differences are compared betwen D versus G+A/G and E versus G+A/G.

  • d P values of <0.1 when mean between-assay differences are compared between strata.

  • e Total number of samples with available data for each stratum.