Table 3

GMC of IgG and GMT of SBA by genotype for TLR3 and CD44 gene SNPs in the initial genetic studya

Gene and SNP_genotypebIgG GMC95% CINo. of individuals with genotypeP valuecSBA GMT95% CINo. of individuals with genotypeP valuec
TLR3
    rs5743312_112.241.94–2.59653ref244.78201.48–297.37634
    rs5743312_121.601.27–2.022230.02172.75123.24–242.152150.08
    rs5743312_221.060.52–2.15210.07415.87193.14–895.46200.35
    rs3775291_111.871.57–2.23425ref201.38157.6–257.32413ref
    rs3775291_122.201.83–2.643950.21242.37189.34–310.253800.30
    rs3775291_222.061.33–3.2760.67325.53186.37–568.6750.13
    rs3775292_112.091.79–2.44565ref231.53188.19–284.85545ref
    rs3775292_122.001.63–2.443030.74234.27175.72–312.332970.95
    rs3775292_221.330.60–2.94290.21112.5839.79–318.53270.14
    rs7657186_111.981.69–2.32551ref236.17192.31–290.03533ref
    rs7657186_122.231.83–2.713150.37233.15174.12–312.193040.94
    rs7657186_221.110.53–2.33300.1095.7135.69–256.66310.04
CD44
    rs353644_112.141.68–2.72230ref264.19191.13–365.19220ref
    rs353644_121.841.55–2.194510.13189.99150.37–240.064370.11
    rs353644_222.321.82–2.962150.63288.14205.06–404.882110.72
    rs11033013_111.861.57–2.21488ref221.94177.79–277.06471ref
    rs11033013_122.111.74–2.543390.35218.9166.87–287.133320.94
    rs11033013_223.102.04–4.72690.04313.5163.27–601.97650.29
    rs996076_111.681.31–2.14246ref234.08170.77–320.85240ref
    rs996076_122.402.00–2.874400.03250.58196.97–318.794210.12
    rs996076_221.761.42–2.192110.76180.42129.22–251.892080.26
    rs12419062_112.371.68–2.35378245.99190.9–316.90365
    rs12419062_121.931.61–2.314110.66202.84158.38–259.774020.29
    rs12419062_220.380.23–0.521070.45272.31168.12–441.081010.71
  • a The samples were analyzed using Student's t test with the geometric mean concentration or geometric mean titer as a continuous variable, without adjustment.

  • b 11, wild-type homozygous genotype; 12, heterozygous genotype; 22, variant homozygous genotype.

  • c ref, referent/baseline group.