Table 1

Seroconversion frequency in mice and ferrets after vaccination

SpeciesVaccine antigen% of animals with seroconversion (no. of animals with seroconversion/total no. of animals of that species) in each cladea
12.12.22.3
MouseCOBRA60 (18/30)100 (30/30)100 (30/30)100 (30/30)
Polyvalent3.3 (1/30)70 (21/30)50 (15/30)53 (16/30)
FerretCOBRA33 (2/6)67 (4/6)50 (3/6)50 (3/6)
Polyvalent0 (0/6)33 (2/6)0 (0/6)0 (0/6)
  • a Percent of animals with a HAI titer dilution of ≥1:40 (no. of responders/total no. of animals).