Table 1

Infectious titer as determined by two in vitro assays for each production lot of virus-antibody complexesa

TreatmentITA (ivp/ml)PLA (PFU/ml)PFU:IVP ratio
Adenovirus alone4.08 ± 0.22 × 10104.5 ± 0.48 × 10101:1.1
Virus + 500 ND501.02 ± 0.52 × 1083.2 ± 0.95 × 1061:32
Virus + 5 ND501.60 ± 0.55 × 1083.6 ± 0.28 × 1061:44
Virus + 0.05 ND502.30 ± 0.92 × 1084.2 ± 0.73 × 1061:55
Virus + 0.005 ND502.53 ± 0.22 × 1010NA
Virus + 0.0005 ND503.62 ± 0.15 × 1010NA
  • a The input for each of these preparations was 1.0 × 1011 virus particles/ml, as determined by measuring the absorbance of each preparation at 260 nm. ITA, infectious titer assay; ivp, infectious virus particles; PLA, plaque assay; NA, not assayed.