Table 4.

Overall diagnostic accuracy and sensitivitya

Type of antibodies or antigensTestSensitivity (%)Specificity (%)PPVbNPVcKappa value
IgM antibodiesMerlin72.7 (62.9-81.2)73.8 (66.2-80.4)63.2 (53.6-72.0)81.4 (74.1-87.4)0.79
Biosynex79.8 (70.5-87.2)46.3 (38.3-54.3)49.9 (40.1-55.8)78.7 (69.1-86.5)0.57
Standard Diagnostics79.2 (70.5-87.2)89.4 (83.5-93.7)82.3 (73.2-89.3)87.7 (81.7-92.3)0.92
Panbio70.7 (60.7-79.4)80.0 (73.0-85.9)68.6 (58.7-77.5)81.5 (74.6-87.3)0.92
NS1 antigenStandard Diagnostics48.5 (38.5-58.7)99.4 (96.6-100)98.0 (89.1-100)75.7 (69.3-81.4)0.96
Bio-Rad58.6 (48.2-68.4)98.8 (95.6-99.9)96.7 (88.5-99.6)79.4 (73.1-84.8)0.94
Panbio58.6 (48.2-68.4)92.5 (87.3-96.1)82.9 (72.0-90.8)78.3 (71.7-84.0)0.95
IgM antibodies and NS1 antigenStandard Diagnostics92.9 (83.9-97.1)88.8 (82.8-93.2)83.6 (75.4-90.0)95.4 (90.6-98.1)Not applicable
    NSI antigenPanbio89.9 (82.2-95.0)75.0 (67.6-81.5)69.0 (60.3-76.8)92.3 (86.3-96.2)Not applicable
  • a The 95% confidence intervals are listed in parentheses.

  • b PPV, positive predictive value.

  • c NPV, negative predictive value.