TABLE 1

SCID foals, plasma donor horses, and plasma infusion schedules

SCID foalImmune plasma donorsaDays plasma was infused (dpi)b
Controls
    C1NoneNone
    C2NoneNone
    C3None−4, −2, 0, 2, 5
Experimental animals
    E1-SH024, H026−4, −2, 0, 2, 5
    E2-SH024, H026−4, −2, 0, 2, 5
    E3-SH024, H026−4, −2, 0, 2, 5
    E4-TH059, H072, H076−4, −2, 0, 2, 5, 7, 9, 11
    E5-TH059, H072, H076−4, −2, 0, 2, 5, 7, 9, 11
    E6-BH024, H026, H059−4, −2, 0, 2, 5, 7, 9, 11, 13
  • a Control SCID foal C3 received nonimmune plasma obtained from horses H024 and H026 before they were infected with T. equi. Immunocompetent horses H024 and H026 were infected with T. equi by i.v. inoculation of parasitized erythrocytes, 1 year before plasma was obtained. Immunocompetent horses H059, H072, and H076 were infected with T. equi by tick transmission 1 year before plasma was obtained.

  • b On each infusion day, donor plasma was pooled and a total of one liter was infused i.v. dpi, days post-T. equi inoculation.