Table 2.

Dissemination of B. burgdorferi in bait-vaccinated white-footed mice (P. leucopus) at termination (day 105)

VaccineaNo. of miceNo. of mice positive/total (%) byb:
Anti-B. burgdorferi IgG (Western blot)Dark-field microscopy of B. borrelia cultureTissue PCR
OspA-RTV (EcA)161/16 (6.25)1/16 (6.25)2/16 (12.5)
Control (Ec)1414/14 (100)10/10 (100)11/12 (91.6)
  • a OspA-RTV (EcA), reservoir targeted vaccine, which is a bait vaccine composed of E. coli cells expressing B. burgdorferi OspA (EcA) mixed with oatmeal; Control (Ec), E. coli cells transformed with empty vector mixed with oatmeal.

  • b P < 0.001 for all intercolumn comparisons by two-tailed Fisher's exact test.