Table 1.

Transmission of B. burgdorferi in ticks that fed on bait-vaccinated white-footed mice (P. leucopus) as determined by OspC-PCR

VaccineaNo. of miceNo. of ticks infected/total (%)b
NIP (nymphal, day 75)LIP (Xenodiagnosis of larvae, day 98)
OspA-RTV (EcA)120/63 (0)*NDc
50/15 (0)2/15 (13)§
125/34 (15)ND
Control (Ec)37/17 (41)*ND
36/9 (67)4/7 (57)§
25/6 (83)ND
  • a OspA-RTV (EcA), reservoir targeted vaccine, which is a bait vaccine composed of E. coli cells expressing B. burgdorferi OspA (EcA) mixed with oatmeal; Control (Ec), E. coli cells transformed with empty vector mixed with oatmeal.

  • b P values were determined by two-tailed Fisher's exact test: *, P < 0.0001; †, P = 0.0006; ‡, P = 0.002; §, P = 0.05.

  • c ND, not determined.