TABLE 1.

Evaluation of assays for detection of IgM against EBVa

Assay and resultNo. of samples with the following IIF result:Sensitivity (%)Specificity (%)Correlation (%)
PositiveNegative
IF, IgM ZEBRA74.010084.0
    Positive570
    Indeterminate120
    Negative848
CLIA-L, IgM p1892.293.892.8
    Positive712
    Indeterminate31
    Negative345
CLIA-I, IgM p1877.995.884.8
    Positive602
    Indeterminate40
    Negative1346
ELISA, IgM p18b67.195.878.5
    Positive491
    Indeterminate51
    Negative1946
  • a For calculating sensitivity and specificity, indeterminate results were considered the most adverse.

  • b For ELISA, data are for 121 results (73 IIF positive and 48 IIF negative).