Table 1.

Immunization strategy and sample collection schedule

Antigen/adjuvantDose per vaccination (μg)nbDays of intranasal vaccinationDays of sampling
SeraMucosal secretions and spleen (n)
IsdA-CTA2/B chimera5080, 100, 10, 14, 4514 (2), 45 (6)
IsdA + CTA2/B17 + 33a80, 100, 10, 14, 4514 (2), 45 (6)
IsdA1780, 100, 10, 14, 4514 (2), 45 (6)
MockNAc80, 100, 10, 14, 4514 (2), 45 (6)
  • a Concentrations (respectively) are according to equimolar amounts of IsdA.

  • b n, number of mice.

  • c NA, not applicable.